AKT1 and cancer: KEGG pathway analysis revealed that the upregulated DEGs were enriched in the MAPKsignaling pathway (hsa04010), while the downregulated genes were significantly enriched in terms 32 pathways in cancer (hsa05200), the PI3K-Akt signaling pathway (hsa04151), neuroactive ligand–receptor interaction (hsa0408), proteoglycans in cancer (hsa05205), HTLV-I infection (hsa05166), Rap1 signaling pathway (hsa04015), transcriptional misregulation in cancer (hsa05202), influenza A (hsa05164), cytokine-cytokine receptor interaction (hsa04060) and axon guidance (hsa04360) (Fig. 5; Fig. S5-sheet 3).