The causal variants at 9p21.3 regulate INK4/ARF expression and influence atherosclerotic vascular disease risk by modulating ANRIL expression, ANRIL can upregulate P14, P15 and P16 gene by recruiting polycomb repressive complex 1 (PRC1) and polycomb repressive complex 2 (PRC2), which are involved in vascular smooth muscle cell proliferation, plaque formation and arterial thrombosis to junctions (Holdt & Teupser, 2018; Holdt et al., 2016; Holdt et al., 2013). This evidence concerns the gene CDKN2A and Venous thrombosis.