Within our study, we observed that, in patients with decompensated cirrhosis, where the mean HCC size was 5.8 cm (maximum tumour diameter ranging between 3.3 and 8.2 cm), AFP levels were mostly over 300 ng/ml, with many values exceeding 500 ng/ml and with a mean AFP of 660 ng/ml. This evidence concerns the gene AFP and neoplasm.