Moreover, the number of nociceptors co-expressing TRPM3 and the two other heat-activated TRP channels TRPA1 and TRPV1 increased in a mouse model of complete Freund’s adjuvant-induced peripheral inflammation, and, interestingly, TRPM3 inhibition reduced TRPA1- and TRPV1-mediated calcium responses in inflamed tissue (Mulier et al., 2020). This evidence concerns the gene TRPM3 and inflammatory response.