HCRT and post-traumatic stress disorder: Since these initial studies revealing the orexin system’s role in critical homeostatic mechanisms, the system’s impact has been further expanded to include roles in addiction, pain, anxiety, panic, depression, binge eating and potentially post-traumatic stress disorder (PTSD) among others (Nakamura et al., 2000; Piccoli et al., 2012; Tsujino and Sakurai, 2013; Fitch et al., 2014; Li et al., 2014; Roh et al., 2014; Sakurai, 2014; Abbas et al., 2015; Bonaventure et al., 2015, 2017; Bonnavion et al., 2015; Soya et al., 2017; Steiner et al., 2018; Kaufmann et al., 2020).