The underlying cause of orexin neuron loss in human narcolepsy is still unknown, however autoimmune-related degenerative processes may play a role (Thannickal et al., 2000; Cvetkovic-Lopes et al., 2010; Lecendreux et al., 2017; Ramberger et al., 2017; Latorre et al., 2018; Luo et al., 2018; Bassetti et al., 2019; Lippert et al., 2019; Mahoney et al., 2019; Pedersen et al., 2019). Here, HCRT is linked to narcolepsy.