In patients with IgM anti-MAG neuropathy, RTX mitigated pain and paresthesia through T reg cell activation (Dalakas et al., 2009), and in patients with multiple sclerosis, B-cell depletion caused inactivation of Th-cell activity in an autoantibody-independent manner (Stuve et al., 2005). The gene discussed is MAG; the disease is neuropathy.