LRRK2 and Parkinson disease: Although the exact mechanism underlying LRRK2-related PD pathogenesis is not fully clear, the G2019S variant has been shown to impair lysosomal functions through phosphorylation of its substrates, especially Rab proteins, which are required for all vesicular trafficking steps (MacLeod et al., 2006) as well as the interaction between mitochondria and lysosomes (Wong et al., 2018).