NR4A1 and acute myeloid leukemia: Importantly, the transcription of 73 genes found to be dysregulated in leukemic stem cells isolated from 9 AML patients (Majeti et al., 2009) was corrected by NR4A1 or NR4A3 overexpression, including MYC and FOXO1 (Boudreaux et al., 2012).