The comparison of transcriptomes of control to co-deleted HSCs revealed that MYC target genes were upregulated in deficient cells, confirming the results obtained in AML cell lines, but also that the gene encoding C/EPBα as well as its associated signature were downregulated in Nr4a1−/−Nr4a3−/− HSCs (Freire and Conneely, 2018). This evidence concerns the gene MYC and acute myeloid leukemia.