While the promoters of NR4A1 and NR4A3 are not targets of hypermethylation (Boudreaux et al., 2019; Shimizu et al., 2016), in NB4, HL60, Kasumi-1, and THP-1 AML cell lines, an intragenic region encompassing exon 3 of NR4A3 is highly methylated (Fig. 5) (Shimizu et al., 2016). This evidence concerns the gene NR4A1 and acute myeloid leukemia.