Given that the increased production of IL-12, TNFα and iNOS by stimulated Nr4a1−/− peritoneal macrophages is sensitive to the NFκB inhibitor Bay-7082 and, as discussed above, given the interplay between NR4As and NFκB signalling, it is likely through the inhibition of this pathway that NR4As modulate the macrophage response and have a positive impact on atherosclerosis (Hanna et al., 2012). Here, NFKB1 is linked to atherosclerosis.