Overexpression of either NR4A1 or NR4A3 in human AML cell lines resulted in decreased cell proliferation and cell survival (Boudreaux et al., 2012; Shimizu et al., 2016) and NR4A3 overexpression reduced the clonogenic potential of hematopoietic progenitors from patients with familial platelet disorder/acute myelogenous leukemia (FPD/AML) (Bluteau et al., 2011), a familial thrombocytopenia with a predisposition to AML. The gene discussed is NR4A1; the disease is acute myeloid leukemia.