The multilayered rosettes showed reactivity for vimentin but non-reactivity for pan-cytokeratin, the zones with abundant neuropil were reactive for synaptophysin consistent with a diagnosis of embryonal tumor with abundant neuropil and true rosettes now ETMR, NOS (WHO Grade 4) due to the lack of genetic testing for amplification of C19MC.<h4>Conclusion</h4>ETMR is a highly aggressive CNS embryonal tumor with extremely poor prognosis. This evidence concerns the gene SYP and embryonal neoplasm.