HMOX1 and COVID-19: On the other hand, the cellular oxidative stress could be attenuated by the Nrf2 and heme oxygenase-1 (HO-1) pathway, which helps in decreasing and maintaining the redox balance in cells thereby reducing inflammation (Yang et al., 2009; Ahmed et al., 2017; Zhang et al., 2021); the activation and increase in Nrf2 expression can suppress and downregulate NLRP3 inflammasomes (Hennig et al., 2018; Yarmohammadi et al., 2021); and the activation of Nrf2 relative pathways can be a strategy to attenuate the infective symptoms of COVID-19.