A recent genome sequencing study also indicated that the spread of double mutations at E484Q/L452R, T478K/L452R, and F490S/L452Q of RBD has the latent potential for the enhancement of viral mutated S protein (Sm) and host ACE2 to form Sm–ACE2 binding (Aggarwal et al., 2021), and concurrently, that may cause more and effective infection of SARS-CoV-2 mutants. The gene discussed is ACE2; the disease is infection.