Mounting evidence obtained from preclinical studies using animal models of lethal pneumonia shows curcumin exerts the protective effects by regulating the expression of both pro- and anti-inflammatory factors such as IL-6, IL-8, IL-10, and COX-2, promoting the apoptosis of polymorphonuclear leukocytes (PMNs) and scavenging ROS which exacerbates the inflammatory response (Liu and Ying, 2020). The gene discussed is IL6; the disease is pneumonia.