PGP and intracranial hemorrhage: Among atypical antipsychotics, quetiapine, and risperidone have similar major bleeding rate ratios, whereas quetiapine has a higher intracranial hemorrhage ARR than that of risperidone, which may be attributed to the feature of quetiapine being a stronger P-gp inhibitor than risperidone (Tsai et al., 2020).