NFKB1 and major depressive disorder: Liu et al. (2014) suggested that total saikosaponins could significantly shorten the immobility time of mice in the TST in a dose-dependent manner by antagonizing reserpine-induced akinesia and ptosis. Various studies have highlighted the association between NF-κB and depression-like behavior (Su et al., 2017). NF-κB plays a vital regulatory role in immune responses, including stress. Activation of NF-κB has been reported to be involved in depressive symptoms (Liu et al., 2017b).