The DM-associated complications, such as high glucose levels, can stimulate ROS generation through PKC and NADPH-dependent pathways in various cells, such as aortic endothelial cells, smooth muscle cells, and renal mesangial cells (N. Jiao et al., 2020; Toma, Sanda, Deleanu, Stancu, & Sima, 2016). Here, PRRT2 is linked to diabetes mellitus.