Recently, we found that APC/C-Cdh1 targets Rock2 for proteasomal degradation in neurons, and that the loss of Cdh1 causes Rock2 stabilization and activation, triggering dendrite disruption, and dendritic spine and synapse loss in the adult brain following neurodegeneration and cognitive impairment (Bobo-Jimenez et al., 2017). Here, CDH1 is linked to Cognitive impairment.