ROCK2 and Alzheimer disease: Given that Rock2 accumulates in the neurons of early-stage human AD brain (Herskowitz et al., 2013) and is associated with AD hallmarks (Gao et al., 2019; Cai et al., 2021), our data showing efficacy of the Rock2 inhibitor, compound SR3677, against Aβ25-35 memory impairment in mice should be considered as a potential therapeutic approach in AD.