It was known that dysregulation of Ca2+ homeostasis is a key event in AD pathogenesis (LaFerla 2002) and that Aβ causes p35 cleavage to p25 -a potent Cdk5 activator- in a Ca2+-dependent manner (Fuchsberger et al., 2016; Lapresa et al., 2019). The gene discussed is CDK5; the disease is Alzheimer disease.