In sum, our work shows that PG, a widely used traditional Chinese medicine, not only reduces the infiltration of PD-1+ CD8 T+ cells by regulating the VEGF-A–VEGFR-2 axis to enhance the killing activity of CD8 T+ cells but also decreases the production of the phosphorylation of STAT3 of tumor cells to mediate the development of tumor growth in the TME. Here, CD8A is linked to neoplasm.