Since ING4 or ING5 has been validated to bind to HBO1 complexes to mediate the anchorage of these complexes on chromatin to regulate chromatin modification and gene transcription (Saksouk et al., 2009), here we sought to explore the regulatory relationship of ING4 with DUSP4, and found that ING4 negatively regulated DUSP4 mRNA and protein expression in RCC cells. Here, ING5 is linked to renal cell carcinoma.