In order to further seek the possible downstream targets in the ING4-mediated activation of RCC CSCs formation, we performed transcriptome sequencing and found that ING4 overexpression resulted in upregulated type I IFN-related responses being enriched at low false discovery rate values and type I IFN-driven ISGs, including IFITM1, IFITM2, MX2, and OAS2, clearly formed a protein interaction core. This evidence concerns the gene IFITM1 and renal cell carcinoma.