To validate the relationship of ING4 with IFITM1, IFITM2, MX2, and OAS2, we tested their mRNA expression in ING4 knockdown and vector control RCC cells, and found that the mRNA expression levels of these genes were significantly suppressed or showed a decreasing trend after ING4 knockdown (Figures 4E,F). The gene discussed is OAS2; the disease is renal cell carcinoma.