When comparing the JZL184 and SAP groups, KEGG showed that the downregulated genes in the SAP group were mainly enriched in human papillomavirus infection, ECM receptor interaction, protein digestion and absorption, focal adhesion, nod-like receptor signaling pathway, PI3K-Akt signaling pathway, hepatitis C, pancreatic secretion, platelet activation, and influenza A (Figure 3A). This evidence concerns the gene AKT1 and human papilloma virus infection.