Activation of pancreatic proteases and dysfunction of pancreatic microcirculation in acute pancreatitis stimulate granulocytes, macrophages, and vascular endothelial cells to release IL-6, TNF-α, and other cytokines that participate in the inflammatory response and immunoregulation (Pooran et al., 2003; Sternby et al., 2021). This evidence concerns the gene IL6 and acute pancreatitis.