The majority of CENPs were significantly aberrantly expressed in ESCC (17/20, 11/13, and 12/13 genes in TCGA, GSE38129, and GSE20347, respectively) (FDR < 0.05 and P < 0.05; Figures 1(a)–1(c)). The gene discussed is CENPS; the disease is esophageal squamous cell carcinoma.