As shown in Figure 4, in the training set, we found that the expression of MCM5, CDCA2, GINS2, and SPC25 (P < 0.05 or P < 0.001) was significantly decreased with the progression of CRC while MCM6 (P > 0.05) had no significance (Figure 4(a)). The gene discussed is SPC25; the disease is colorectal carcinoma.