But in the test set, the expression of MCM5, MCM6, and CDCA2 (P <0.05 or P < 0.001) was negatively correlated with CRC stage, while the expression of GINS2 and SPC25 (P > 0.05) was not significantly correlated with tumor stage (Figure 4(b)). Here, SPC25 is linked to neoplasm.