Based on the close linkage among OPG/RANK/RANLK/TRAF6 pathway, osteoblast, and adipocyte, we treated the ovariectomized rats with Gds for 90 days, the liquid chromatography coupled with as spectrometry (LC-MS/MS) was used as an “omics” tool to reveal the specific metabolites associated with osteoporosis (16). Here, TNFRSF11A is linked to osteoporosis.