INS and type 2 diabetes mellitus: In T2DM, there were 465 patients taking insulin and 1,436 patients taking glucose-lowering pills, with a few in prediabetes also doing so For example, sulfonylureas, such as gliclazide and glimepiride, were reported to have an association with hypoglycemia (30) and weight gain at the same time of their actions on β-cells to stimulate insulin secretion (31).