We found 7 exclusive KEGG pathways in the interaction between DE-mRNA and EVOO-miRNA-EVs [melanoma (hsa05218), notch signaling (hsa04330), renal cell carcinoma (hsa05211), endocytosis (hsa04144), chemokine signaling (hsa04062), prostate cancer (hsa05215) and neurotrophin signaling (hsa04722)]. The gene discussed is BDNF; the disease is renal cell carcinoma.