Apiin also alleviates insulin resistance in HFD mice via downregulation of glucogenic genes, PEPCK (phosphoenolpyruvate carboxykinase) and G6Pase (glucose-6-phosphatase) in the liver, and promotion of glycogen synthesis via inhibition of glycogen synthase phosphorylation and induction of GSK3β (glycogen synthase kinase3β) phosphorylation (116). The gene discussed is G6PC1; the disease is Insulin resistance.