Both non-enzymatic antioxidants of AsA and GSH have their redox potentials to detoxify H2O2 and maintain ROS homeostasis, and the maintenance of their redox state is contributed to enhancing host resistance of plants response to fungal infection, which directly depends on the activities of six important AsA-GSH cycle-related enzymes, namely, APX, GR, MDHAR, DHAR, GST, and GXP that participate in eliminating harmful H2O2 (Hasanuzzaman et al., 2019; Sadeghi et al., 2020; Zhu et al., 2022). Here, APEX1 is linked to fungal infectious disease.