The functional capacities of the highly expressed DEGs in the Chinese Simmental cattle mainly focused on inflammatory diseases (CXCL9 and FCRL1), immunodeficient diseases (ADM2, CCL5, and CAMKV), carcinoma (CXCL11, JAKMIP2, GZM, and DNAAF1), and GTP binding and GTPase activity (NUGGC). This evidence concerns the gene CAMKV and immunodeficiency disease.