Genetic studies have revealed some potential genetic risk factors in IBD patients, including NOD2, CARD9, ATG16L1, IRGM, and FUT2 (Xavier and Podolsky, 2007), which are indeed significantly associated with the decrease in the genus Roseburia, who plays an essential role in the conversion of acetate to butyrate. The gene discussed is ATG16L1; the disease is inflammatory bowel disease.