IL10 and neoplasm: Dysfunctional interaction of tumor and stromal cellular components leads to a predominantly anti-inflammatory cytokine profile with interleukin-10 (IL-10) (Seo et al., 2001), transforming growth factor (TGF)-beta and other cytokines (Strauss et al., 2007), produced by immunosuppressive cells, for example, regulatory T cells (Tregs) (Knol et al., 2011).