Evidence from our studies indicates that the combined use of interferon-β (IFNβ) and p19Arf (alternate reading frame, p19Arf in mice and p14ARF in humans) induces melanoma cell death by necroptosis and is associated with an anti-viral response and the release of immunogenic factors (such as HMGB1, ATP and calreticulin) (Merkel et al., 2013; Ribeiro et al., 2017; Cerqueira et al., 2020). This evidence concerns the gene IFNB1 and melanoma.