PTEN and melanoma: In another study, the whole genome sequence analysis of melanoma samples also found mutations in other genes, such as TERT, TP53, CDKN2A and CDKN2B. Some of these mutations as BRAF, NRAS and TERT are also found in benign lesions whereas CDKN2A, TP73 and PTEN are observed only in invasive melanoma (Amaral et al., 2017; Consortium, 2020).