Furthermore, Fang LP found that exogenous administration of H2S suppressed TGF-β1 mediated EMT and preincubation with H2S decreased the phosphorylation of Smad2/3 induced by TGF-β1 in human lung carcinoma (A549) cells (Fang et al., 2010). This evidence concerns the gene TGFB1 and lung carcinoma.