In Figure 6, we selected the top 10 genes with mutation frequency greater than 3%, e.g., IDH, TERT-p and O-6-methylguanine-DNA methyltransferase promoter (MGMT-p) and some tumor-specific genes, e.g., tumor protein p53 (TP53) and phosphatase and tensin homolog (PTEN). The gene discussed is IDH1; the disease is neoplasm.