IgE-mediated allergies are among those increasing in prevalence; globally, IgE-mediated sensitization to environmental allergens (e.g. pollen) affect up to 40% of individuals (Pawankar et al., 2013), and IgE-mediated food sensitization affects up to 10% of children, and 6% of adults (Osborne et al., 2011; Prescott et al., 2013; Lee, 2017; Waserman et al., 2018). The gene discussed is IGHE; the disease is allergic disease.