GPR143 and Parkinson disease: Goshima et al. also observed GPR143-immunoreactive signals, in both control and PD brains, in the entire midbrain region including the substantia nigra pars compacta (Goshima et al., 2019b), a basal ganglia structure and contains dopaminergic neurons that produce neuromelanin (Rabey and Hefti, 1990).