Stimulation of the RAS/RAF/mitogen activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway by the Epidermal Growth Factor (EGF) and Platelet Derived Growth Factor (PDGF), which play a role in proliferation and survival of tumor cells, resulted in enhanced GPR143 expression and migration of the melanoma cells (Bai et al., 2014). The gene discussed is GPR143; the disease is melanoma.