identified significant links between the BC risk and the expression of RCCD1 (RCC1 domain containing 1) and DHODH (dihydroorotate dehydrogenase) in the breast tissue, along with association with ANKLE1 (Ankyrin Repeat and LEM Domain Containing 1) in trans-ethnic meta-analyses of U4C, and UK Biobank data were elucidated (Hoffman et al., 2017). The gene discussed is ANKLE1; the disease is breast cancer.