ESR1 and neoplasm: This test includes the expression of eight tumor-associated genes including BIRC5, UBE2C, RBBP8, AZGP1, IL6ST, MGP, DHCR7, and STC2 and three control genes OAZ1, CALM2, and RPL37A. This test is used in determining the prognosis of women with estrogen receptor-positive and lymph node ± disease (Filipits et al., 2011).