These models, for example, Stockholm3, Prostate Cancer Prevention Trial Risk Calculator, Prostate Biopsy Collaborative Group Risk Calculator, European Randomised Study of Screening for Prostate Cancer, 4K, and Prostate Health Index, have shown favorable results compared with PSA to detect clinically significant prostate cancer (csPCa) [4], [5], [6], [7], [8], [9]; at the same time, these have been shown to reduce the number of biopsies performed and International Society of Urological Pathology (ISUP) grade 1 cancers diagnosed [10]. The gene discussed is KLK3; the disease is Familial prostate cancer.