In particular, the same DHCR7 VUS (c.988G > A) was spotted in two patients (P09, born with only one functional kidney, and P26), both diagnosed with low-risk epithelial fetal HB; this gene encodes an enzyme that catalyzes the conversion of 7-dehydrocholesterol to cholesterol (Fitzky et al., 1998) and is a candidate for familial breast cancer in BRCA1-and BRCA2-negative breast cancer families (Shahi et al., 2019), in a recessive mode of action. This evidence concerns the gene BRCA1 and hereditary breast carcinoma.