RB1 and cancer: Germline mutations have been detected in 8–18% of children and adolescents with cancer (Zhang et al., 2015; Akhavanfard et al., 2020; Capasso et al., 2020; Newman et al., 2021), and the most prevalent CPGs reported to be mutated are TP53, APC, BRCA2, NF1, PMS2, RB1, and RUNX1 (Zhang et al., 2015).