Germline mutations have been detected in 8–18% of children and adolescents with cancer (Zhang et al., 2015; Akhavanfard et al., 2020; Capasso et al., 2020; Newman et al., 2021), and the most prevalent CPGs reported to be mutated are TP53, APC, BRCA2, NF1, PMS2, RB1, and RUNX1 (Zhang et al., 2015). The gene discussed is RUNX1; the disease is cancer.