APC and hemoglobin measurement: An increased risk for HB development has been reported in association with a few specific genetic conditions, including Beckwith-Wiedemann syndrome (DeBaun and Tucker, 1998; Kim et al., 2017), familial adenomatous polyposis (APC gene) (Hirschman et al., 2005), Li-Fraumeni syndrome (TP53 gene) (Curia et al., 2008), Aicardi syndrome (Kamien and Gabbett, 2009), and trisomy 18 (Pereira et al., 2012).