Finally, nine SNPs related to nine miRNA genes of PI3K/Akt (rs107822 in miR-219a, rs10877887 in let-7i, rs2292832 in miR-149, rs353293 in miR-143, rs3746444 in miR-499, rs3803808 in miR-132, rs4078756 in miR-10b, rs629367 in let-7a, and rs7372209 in miR-26a) were selected, and the association of SNPs with CIN and CC was evaluated in a Chinese population. Here, PIK3CA is linked to cervical squamous intraepithelial neoplasia.