MALAT1 (ranked third) promotes the survival of CML cells, stimulates the cell cycle and imatinib resistance by sponging miR-328, highlighting the vital roles of MALAT1 as a microRNA sponge in CML and supporting the application of lncRNA-targeted therapies in the treatment of CML (Wen et al., 2018). The gene discussed is MALAT1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.