A recent study showed that IFI44 can serve as a key biomarker for LN from IgA nephritis and healthy controls, and was associated with LN disease activity (Shen et al., 2021), suggesting that IFI44 was not only involved in the damage of immune complexes to the kidney but also closely related to the pathogenesis of SLE. Here, IFI44 is linked to lobular neoplasia.