So far, more than 300 cases of PDE, 87 cases of PNPO deficiency, and 44 cases of PLPBP deficiency have been reported, respectively (Heath et al., 2020; Jiao et al., 2020; Alghamdi et al., 2021). This evidence concerns the gene PLPBP and hyperinsulinemic hypoglycemia, familial, 4.