DOT1L and melanoma: Further investigations of the role of DOT1L in melanomagenesis revealed that its inhibition alone does not affect the growth of primary melanocytes or most melanomas, but the presence of activated oncogene BRAFV600E or ultraviolet radiation (UVR) facilitates oncogenic transformation of DOT1L-depleted melanoma cell both in vitro and in vivo (Zhu et al., 2018).