DOT1L and neoplasm: In apparent contrast with the results reported above, Wang et al. reported that complete loss of DOT1L expression in OC promotes cell invasion and stemness through the downregulation of E-cadherin and TJP1 and the upregulation of ALDH1A1 expression by Wnt signaling activation, suggesting that this enzyme could exert also tumor suppressive role in certain OC cells types (Wang X. et al., 2019).