More recently, Serresi and coworkers performed in lung cancer cells a large-scale CRISPR interference (CRISPRi) screen for genes involved in epigenome regulation, to identify factors required for the proper regulation of EMT and found that loss of DOT1L affects epithelial mesenchymal homeostasis, cellular fitness, and migration (Serresi et al., 2021). Here, DOT1L is linked to lung cancer.