Involvement of DOT1L in gastric cancer has been well elucidated by a recent work, demonstrating a direct correlation between the level of this gene mRNA and tumor differentiation grade, TNM staging, and lymph node metastases, providing a clinical demonstration that DOT1L expression may represent an independent prognostic marker of OS in gastric cancer patients (Song et al., 2020). The gene discussed is DOT1L; the disease is neoplasm.