DOT1L and ovarian carcinoma: Interestingly, high DOT1L expression has been shown to represent a biomarker of poor prognosis also in other gynecological malignancies, in particular ovarian cancer (Zhang et al., 2017), where the expression of DOT1L has been associated with chemoresistance (Liu D. et al., 2018) and shorter relapse-free (RFS) and overall (OS) survival (Alexandrova et al., 2020; Chava et al., 2021).