DOT1L and melanoma: DOT1L has been shown to exert a protective role during UV-induced melanomagenesis, since in the absence of this enzyme UVR-induced DNA damage is inefficiently repaired (Zhu et al., 2018) and missense mutations of DOT1L gene were found in 4.4–15% of melanoma cases from publicly available sequence databases, such as The Cancer Genome Atlas (TCGA) and Broad Institute Databases (Hodis et al., 2012; Shain et al., 2015; Zhu et al., 2018).