MYCN and neuroblastoma: These authors found also that DOT1L induces H3K79me2 in the promoter region of the N-Myc target ODC1 and E2F2 genes, where in complex with N-Myc itself, it activates the transcription of these genes, confirmed by the finding that depletion or pharmacological inhibition of DOT1L inhibits proliferation of MYCN-amplified neuroblastoma cells both in vitro and in vivo.