These studies demonstrated that treatment of CD44v3highALDH1high HNSCC cells with matrix hyaluronan (HA) enhanced CSC-like properties, induced upregulation of DOT1L followed by H3K79 monomethylation on E-box elements located in promoter of miR-10b, resulting in the production of this miRNA (Ma et al., 2007). Here, DOT1L is linked to head and neck squamous cell carcinoma.