Altogether, these data indicate that in gynecologic cancers DOT1L may act via the regulation of expression of genes involved in cell cycle progression, cell death, EMT, stemness, metabolism, oxidative stress response, and drug-resistance through direct binding to transcriptional factors or other cofactors, and might represent a potential prognostic biomarker and potential therapeutic target. The gene discussed is DOT1L; the disease is female reproductive organ cancer.