DOT1L and neoplasm: Interestingly, it has been recently demonstrated how the expression of DOT1L can be regulated by small noncoding RNAs, such as miR-133b, a microRNA with a tumor suppressor role, whose activity determines the downregulation of DOT1L at both mRNA and protein level, regulating CRC stemness and chemoresistance (Lv et al., 2019).