CD177 and neoplasm: This anti-EMT effect of the HMT was confirmed by its ability to downregulate PD-L1, associated with an inflammatory tumor microenvironment in lung adenocarcinoma (Lou et al., 2016), the cell surface receptor NRP2, and its ligand SEMA3C, both known for their role in EMT induction (Nasarre et al., 2013; Neufeld et al., 2016).