This approach is validated by the observation that known SMYD3 interactors, such as VGFR1, which is involved in cancer hallmark “inducing angiogenesis”, and ATM and BRCA2, which are involved in cancer hallmark “genome instability & mutation”, show a significant enrichment in P-tripeptides (Fig. 2 and Appendix Tables S6 and S7) [23], [28]. The gene discussed is BRCA2; the disease is cancer.