Aggregation, cellular mislocalization and loss of nuclear TDP-43 (TAR DNA binding protein) are hallmarks of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) (Arai et al., 2006; Neumann et al., 2006) and limbic-predominant age-related TDP-43 encephalopathy (LATE) (Nelson et al., 2019). Here, TARDBP is linked to amyotrophic lateral sclerosis.