According to the analysis of clinical data, the potential pharmacological effects have been found in TCM for treating insomnia through the regulation of neurotransmitters and their receptors in the brain, including γ- aminobutyric acid, serotonin, orexin, acetylcholine (Shi et al., 2014; Singh and Zhao, 2017). This evidence concerns the gene HCRT and insomnia measurement.