We found that nine patients (37.5%) were oligogenic for other ALS genes (Table 3); in particular, two carried the pathological expansion of the C9orf72 gene and one of them carried also the p.Ile70Val missense in the ANG gene, which was classified as presumed pathogenic (Greenway et al., 2006; Crabtree et al., 2007; Paubel et al., 2008). Here, C9orf72 is linked to amyotrophic lateral sclerosis.