NEK1 LoF variants have been previously proposed to play a pathogenic role in ALS, since several studies described a significantly higher frequency in both patients with fALS and sALS compared with controls, with a prevalence ranging from 0.4 to 1.8% (Brenner et al., 2016; Kenna et al., 2016; Nguyen et al., 2018; Shu et al., 2018; Naruse et al., 2019; Tsai et al., 2020; Lattante et al., 2021). Here, NEK1 is linked to amyotrophic lateral sclerosis.