The observed plasma NfL levels in individuals with Wolfram syndrome overlap with similar-aged, untreated children with pediatric MS (Reinert et al., 2020) and appear similar to those in people with asymptomatic spinocerebellar ataxia type 3 [median (IQR) NfL = 12.2 (10.2–13.9) pg/mL] (Peng et al., 2020). This evidence concerns the gene NEFL and myeloid sarcoma.