NfL levels are not associated with a specific disease etiology but instead are sensitive to progressive neurodegeneration and may predict onset or progression across many diseases, such MS in adults and children, Alzheimer’s disease (AD), Huntington disease, amyotrophic lateral sclerosis, and spinocerebellar ataxia (Disanto et al., 2017; Mattsson et al., 2017; Ashton et al., 2019; Bridel et al., 2019; Gaetani et al., 2019; Gordon, 2020; Reinert et al., 2020; Coarelli et al., 2021). This evidence concerns the gene NEFL and Alzheimer disease.