In the spectrum of CNS SOL biopsies that we received, extremely rare and unusual cases of extradural Rosai-Dorfman disease, PNET of D4-D5, SEGA, adenoid cystic carcinoma of orbit, ganglioglioma, anaplastic oligodendroglioma, gangliocytoma with pituitary adenoma, psammomatous meningioma of thoracic vertebrae, embryonal tumor NOS, meningioma with rhabdoid differentiation, gliosarcoma, anaplastic meningioma, metastatic squamous cell carcinoma, cavernous angioma, mucin-secreting metastatic carcinoma, and few other rare entities were also diagnosed. This evidence concerns the gene MUC5AC and gliosarcoma.