NR0B1 and hypogonadotropic hypogonadism: As DAX-1 plays an important role in the development and function of the adrenal, as well as the hypothalamic-pituitary-gonadal axis, males affected with DAX-1(NR0B1) gene mutation also suffer from hypogonadotropic hypogonadism and cryptorchidism due to selective deficiency of gonadotropins (LH and FSH) [5].