CRP and myocardial infarction: The Canakinumab Anti-Inflammatory Thrombosis Outcomes Study (CANTOS) clinical trial is a randomized, double-blind study that recruited 10,061 patients with a previous diagnosis of myocardial infarction, along with elevated C-reactive protein levels of 2 mg/l. Patients were either given canakinumab, a monoclonal antibody targeting interleukin (IL)-1, or a placebo.