F5 and cirrhosis of liver: One study correlated hypercoagulability to Child-Pugh Classification, suggesting that worsening liver function may reflect an increasing prothrombotic profile in patients with liver cirrhosis. The extent of hypercoagulability in cirrhotic patients with Child-Pugh class C was similar to that observed in the plasma of patients with congenital protein C deficiency or factor V Leiden mutation [9].