To improve SIHD outcomes, 2002 Chronic Stable Angina Guideline and 2007 Focused Update of the American College of Cardiology (ACC)/American Heart Association (AHA) 2002 Guideline for the Management of Patients With Chronic Stable Angina, recommended optimal medical therapy (OMT), including anti-platelet agents, beta-adrenergic antagonists, angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs), and statins [2,3]. The gene discussed is ACE; the disease is angina pectoris.