Since no information is available regarding immunohistochemical localization of SphK2, SGPP1, and LPP3 in OSCC, thus, in the present study, we have analyzed the expression of SphK1, SphK2, SGPP1, and LPP3 in tumor tissues from OSCC patients and benign oral mucosa by immunohistochemistry (IHC). This evidence concerns the gene SPHK1 and neoplasm.