Similarly, our previous work noted that when mice were fed the high-cholesterol diet (HCD) supplemented with the Thr derivative at 0.1 or 0.2 mg per g-mouse per day for 10 weeks, both the total and LDL levels were reduced and weight gain was also decreased up to 17.3% compared to the HCD group.26 Considering these beneficial effects of Thr derivative consumption on dietary, cholesterol, and CETP inhibition, the Thr derivative sufficiently contributes to increase the anti-obesity effect when it is combined with the Trp derivative. This evidence concerns the gene CETP and obesity due to melanocortin 4 receptor deficiency.