In typical PCa cell lines such as PC-3 (bone metastasis of a grade IV PCa) it has been shown that there are severely upregulated GRPR, other PCa cell lines, whereas the LNCaP cell line (lymph node metastasis of a prostate adenocarcinoma) express the GRPR to a lower level. The gene discussed is GRPR; the disease is prostate adenocarcinoma.