VEGFA and neoplasm: Figure 10 shows the two different targeting pathways (Wicki et al., 2015). Vascular Endothelial Growth Factor (VEGF) shows to be essential for the progression of the disease as it regulates the formation of blood vessels to provide tumour sites with nutrients for further growth. The accumulation of these agents on surface of permeable abnormal blood vessels of tumour tissues via the Enhanced Permeability and Retention Effect (EPR) is known as the passive targeting.